Table 1 The incidence of CLL in 1990 and 2019 and its temporal trends

Overall

405.37 (371.18–427.52)

0.76 (0.69–0.80)

1034.67 (934.64–1189.42)

1.34 (1.21–1.54)

1.86 (1.79–1.92)

Sex

 Male

215.53 (187.96–229.36)

0.80 (0.70–0.85)

552.83 (488.69–665.21)

1.42 (1.26–1.71)

1.78 (1.71–1.85)

 Female

189.85 (175.20–204.20)

0.71 (0.66–0.77)

481.84 (427.87–552.37)

1.25 (1.11–1.43)

1.93 (1.86–1.99)

Socio-demographic factor

 High SDI

236.29 (216.67–252.13)

2.87 (2.64–3.07)

443.87 (384.09–545.65)

4.38 (3.79–5.38)

1.11 (1.08–1.15)

 High-middle SDI

102.93 (92.68–112.12)

0.89 (0.81–0.97)

306.56 (276.18–343.40)

2.14 (1.93–2.40)

3.13 (3.07–3.18)

 Middle SDI

31.21 (26.08–36.15)

0.18 (0.15–0.21)

154.59 (135.14–179.99)

0.65 (0.56–0.75)

5.19 (5.07–5.32)

 Low-middle SDI

23.75 (19.78–28.18)

0.21 (0.18–0.25)

82.58 (71.86–95.17)

0.47 (0.41–0.54)

2.84 (2.71–2.97)

 Low SDI

11.02 (8.74–13.48)

0.21 (0.17–0.26)

32.86 (27.61–38.60)

0.29 (0.24–0.34)

1.27 (1.13–1.41)

Region

 Andean Latin America

0.35 (0.29–0.44)

0.09 (0.08–0.12)

1.99 (1.54–2.49)

0.31 (0.24–0.39)

4.65 (4.48–4.82)

 Australasia

6.06 (5.50–7.02)

2.99 (2.71–3.46)

15.18 (11.84–19.98)

5.22 (4.07–6.87)

1.55 (1.52–1.58)

 Caribbean

1.48 (1.32–1.63)

0.42 (0.37–0.46)

3.73 (3.09–4.52)

0.79 (0.65–0.96)

2.31 (2.22–2.40)

 Central Asia

2.32 (1.94–2.61)

0.33 (0.28–0.38)

4.94 (4.12–6.00)

0.53 (0.44–0.64)

1.61 (1.51–1.72)

 Central Europe

17.30 (15.70–20.20)

1.41 (1.28–1.64)

64.36 (54.75–78.94)

5.63 (4.79–6.91)

4.99 (4.95–5.03)

 Central Latin America

2.27 (2.03–2.41)

0.14 (0.1–0.15)

9.59 (7.94–11.77)

0.38 (0.32–0.47)

3.43 (3.29–3.57)

 Central Sub-Saharan Africa

0.60 (0.41–0.91)

0.11 (0.07–0.16)

2.94 (1.97–4.26)

0.22 (0.15–0.32)

2.61 (2.44–2.78)

 East Asia

20.22 (15.23–26.47)

0.17 (0.12–0.22)

162.14 (133.32–199.11)

1.10 (0.91–1.35)

7.98 (7.86–8.10)

 Eastern Europe

37.52 (30.60–44.07)

1.66 (1.35–1.95)

74.24 (65.51–84.31)

3.54 (3.12–4.02)

2.85 (2.81–2.89)

 Eastern Sub-Saharan Africa

4.15 (3.18–5.22)

0.22 (0.17–0.27)

12.70 (10.31–15.83)

0.31 (0.25–0.38)

1.27 (1.14–1.41)

 High-income Asia Pacific

4.58 (4.25–5.54)

0.26 (0.24–0.32)

12.67 (10.38–15.68)

0.68 (0.55–0.84)

3.27 (3.17–3.37)

 High-income North America

122.10 (110.16–129.00)

4.35 (3.92–4.59)

207.23 (174.82–255.27)

5.68 (4.80–7.00)

0.41 (0.38–0.44)

 North Africa and Middle East

6.94 (5.50–8.51)

0.20 (0.16–0.25)

31.52 (26.99–37.75)

0.52 (0.44–0.62)

3.40 (3.28–3.52)

 Oceania

0.02 (0.02–0.03)

0.03 (0.02–0.04)

0.05 (0.04–0.07)

0.04 (0.03–0.05)

0.25 (− 0.11–0.62)

 South Asia

26.94 (22.35–32.58)

0.25 (0.20–0.30)

97.47 (82.93–113.40)

0.54 (0.46–0.63)

2.71 (2.59–2.83)

 Southeast Asia

4.31 (3.57–5.25)

0.09 (0.08–0.11)

19.17 (15.35–4.23)

0.28 (0.23–0.36)

3.99 (3.81–4.16)

 Southern Latin America

2.73 (2.37–3.07)

0.55 (0.48–0.62)

6.10 (4.77–7.89)

0.91 (0.71–1.18)

1.25 (1.17–1.32)

 Southern Sub-Saharan Africa

3.78 (3.20–4.34)

0.72 (0.61–0.83)

9.19 (7.91–10.41)

1.17 (1.01–1.32)

1.83 (1.77–1.90)

 Tropical Latin America

3.19 (2.93–3.41)

0.21 (0.19–0.22)

12.64 (11.13–14.69)

0.57 (0.50–0.66)

3.57 (3.45–3.68)

 Western Europe

134.28 (123.30–142.03)

3.49 (3.21–3.69)

275.60 (235.01–338.18)

6.32 (5.39–7.75)

1.79 (1.76–1.82)

 Western Sub-Saharan Africa

4.25 (3.47–4.98)

0.22 (0.18–0.26)

11.23 (8.99–13.34)

0.25 (0.20—0.25)

0.41 (0.27–0.55)