From: MXene in the lens of biomedical engineering: synthesis, applications and future outlook
Type of MXene/MXene composite | Synthesis method of MXene | Functionalization(s) | Application | Application details | Ref |
---|---|---|---|---|---|
TiO2–Ti3C2 | Hydrothermal synthesis | Hemoglobin (Hb), Nafion | Bio-sensor | Detection of hydrogen peroxide (LOD: 14 nM; range: 0.1–380 μM) and nitrite (LOD: 0.12 μM; range: 0.1–380 μM) via amperometry changes | |
Au/Ti3C2 | HF etching | Glucose oxidase (GOx) | Detection of hydrogen peroxide through oxidation of glucose (LOD: 5.9 μM; range: 0.1–18 mM) | [46] | |
Ti3C2 | LiF + HCl etching | Poly-L-lysine (PLL), GOx | Detection of hydrogen peroxide through oxidation of glucose (LOD: 2.6 μM; range: 4–20 μM, 0.02–1.1 mM) | [47] | |
Ti3C2 | HF etching | Tyrosinase, chitosan | Detection of phenol in real water samples (LOD: 12 nM; range: 0.05–15.5 μM) | [48] | |
Ti3C2 | HF etching | β-hydroxybutarate dehydrogenase, bovine serum albumin (BSA), glutarate | Detection of β-hydroxybutarate (LOD: 44.5 μM; range: 360 μM–17.91 mM) | [49] | |
Ti3C2 | LiF + HCl etching | (3-Aminopropyl) triethoxysilane (APTES), BSA, anti-CEA | Detection of carcinoembryonic antigen (CEA) (LOD: 1.8 × 10–5 ng mL−1; range: 0.0001–2000 ng mL−1) | [50] | |
Ti3C2 | HF etching, TMAOH intercalation | AuNPs, staphylococcal protein A, anti-CEA | Detection of CEA via surface plasmon resonance (SPR) (LOD: 0.7 fM; range: 0.0002–20 000 pM) | [51] | |
Ti3C2 | HF etching | Hollow AuNPs, APTES, SPA, anti-CEA | Detection of CEA via SPR (LOD: 0.15 fM; range: 0.001–1000 pM) | [52] | |
Ti3C2 | HF etching, DMSO intercalation | Osteopontin (OPN) aptamer, phosphomolybdic acid (PMo12), polypyrrole (PPy), | Detection of overexpressed OPN (LOD: 0.98 fg mL−1; range: 0.005 pg mL−1–10 ng mL−1) | [53] | |
Ta4C3 | HF etching | Manganese oxide (MnOx), soybean phospholipid (SP) | Cancer theranostics | Multi-imaging-guided (MRI, CT scan and PAI) PTT | [54] |
Ti3C2 | HF etching, TPAOH intercalation | Manganese oxide (MnOx), soybean phospholipid (SP) | MRI-guided PTT | [55] | |
Ta4C3 | HF etching | Supermagnetic iron oxide nanoparticles (IONPs) | MRI-guided PTT | [56] | |
Ti3C2 | HF etching, TPAOH intercalation | Poly(lactic-co-glycolic acid) (PLGA), SP, IONPs | MRI-guided PTT | [34] | |
Nb2C | HF etching, TPAOH intercalation | Polyvinylpyrrolidone (PVP) | PAI-guided PTT | [57] | |
Nb2C | HF etching, TPAOH intercalation | Cetanecyltrimethylammonium chloride (CTAC), APTES, polyethylene glycol (PEG) | PAI-guided PTT | [58] | |
Ti3C2 QDs | Hydrothermal synthesis | – | Multicolour cellular imaging | [59] | |
Ti3C2 QDs | Sonication probing in TPAOH | – | PTT in NIR biowindow, biocompatibility test | [60] | |
Ti2N QDs | KF + HCl etching, sonication in NMP | SP | PAI-guided PTT | [61] | |
Nb2C QDs | HF etching, TPAOH sonication (ultrasound-assisted) | – | Fluorescence imaging, metal ions sensing | [62] | |
Ti3C2 | HF etching, TPAOH intercalation | SP, doxorubicin (Dox) | Drug delivery | Chemotherapeutic agent, synergistic chemotherapy and PTT | [63] |
Ti3C2 | HF etching | Cellulose, Dox | Chemotherapeutic agent, synergistic chemotherapy and PTT | [64] | |
Ti3C2 | HF etching | Polyacrylamide (PAM) | Study of drug release | [65] | |
Ti3C2 | LiF + HCl etching | Cobalt nanowires (CoNWs), Dox | Study of drug release control, synergistic chemotherapy and PTT | [66] | |
Ti3C2 | LiF + HCl etching | – | Antimicrobial activity | Study of antibacterial activity | [67] |
Ti3C2 | LiF + HCl etching | PVDF | For wastewater treatment | [68] | |
Ti3C2 | LiF + HCl etching | Chitosan, glutaraldehyde | Study of antibacterial activity | [69] | |
Ti3C2, Ti2C | HF etching | – | Comparison study of antibacterial activity | [70] | |
Ti3C2 | HF etching | PLL | Study of antibacterial activity | [22] | |
Ti3C2 | LiF + HCl etching | – | Study of antibacterial activity | [71] | |
Ti3C2 | HF etching | – | Study of antifungal activity | [20] |