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Fig. 3 | BioMedical Engineering OnLine

Fig. 3

From: Organ-on-a-chip: recent breakthroughs and future prospects

Fig. 3

(reprinted with permission from [76] Copyright © 2018, Royal Society of Chemistry)

a Kidney tubular chip. Sandwich assembly of the PDMS channel, porous membrane, and PDMS reservoir (reproduced from [74]); b the channel can replicate the urinary cavity and capillary lumen of the glomerulus. The porous flexible PDMS membrane can be used to functionalize the protein laminin to mimic the glomerular basement membrane. Cyclic mechanical pressure to the cell layer via vacuum stretching of the flexible PDMS film can be produced

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