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Figure 4 | BioMedical Engineering OnLine

Figure 4

From: Gap-junction channels inhibit transverse propagation in cardiac muscle

Figure 4

Transverse propagation of simulated APs for cardiac muscle with stimulation simultaneously of the entire A-chain. This was done as a better assessment of transverse propagation for comparison with stimulation of only one cell of the A-chain. A: Rgj = ∞ (0 channels). Rol2 = 200 KΩ. Standard conditions. All 5 chains responded. B: Rgj = 1.0 MΩ (10,000 channels). With Rol2 kept at 200 KΩ, chains C, D, and E failed to respond. C: With Rgj held at 1.0 MΩ, raising Rol2 to 10 MΩ (representing tighter packing of the chains) now allowed all 5 chains to respond. All 5 cells of each chain responded simultaneously because of the strong coupling. Thus, adding gj-channels inhibited transverse propagation, but this inhibition was overcome by raising Rol2.

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