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Figure 9 | BioMedical Engineering OnLine

Figure 9

From: Transverse propagation of action potentials between parallel chains of cardiac muscle and smooth muscle cells in PSpice simulations

Figure 9

Propagation of smooth muscle action potentials (APs) in the 5 × 5 model (5 parallel chains of 5 cells each) when the first cell of the E chain (cell E1) is electrically stimulated (0.5 nA, 0.5 ms rectangular current pulse applied internally). PSpice simulation. A: V recording markers placed on the A-chain cell units only. B: V markers on the B-chain only. C: V recording from the C-chain only. D: V recording from D-chain. E: V recording from E-chain. F: V recording from all 5 chains simultaneously. All parameters were the standard values (Rjc = 10 MΩ; Rol2 = 100 KΩ). Note that excitation spreads from the E-chain to the D-chain after a delay (from first response of A-chain) of about 5.0 ms, and that excitation spreads from the D-chain to the C-chain after a delay (from first response of D-chain) of about 3.7 ms. Once excitation entered the D, C, B and A chains, it propagated very quickly over the 5 cells of each chain. The effect of bunching of the APs is greatest in the last chain (A-chain).

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