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Figure 6 | BioMedical Engineering OnLine

Figure 6

From: Transverse propagation of action potentials between parallel chains of cardiac muscle and smooth muscle cells in PSpice simulations

Figure 6

Graphic summary of the effects of varying Rol2 (A), Ror2 (B), and Rjc (C) on the total propagation time (TPT) over the first 15 cells (TPT15) of the 25-cell network (5 × 5 model) of cardiac muscle cells. As shown in A, TPT decreased as Rol2 (longitudinal resistance of the interstitial space between chains of the bundle) was increased (reflecting tighter packing of the chains). Hence, average velocity of propagation was increased. Elevation of Ror2 (transverse resistance of the interstitial space) had only a slight effect on TPT (B), indicating that transverse current flow was small and not important to transverse transmission. Elevation of Rjc (radial shunt resistance of the junctional cleft) decreased TPT. A high Rjc value reflects a narrow junctional cleft. TPT was measured over only 15 cells, because in a few cases, failure occurred between chains C and D or between D and E.

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